Carcinoma-in-situ of the testis diagnosis and screening. by Edward Thomas Brackenbury

Cover of: Carcinoma-in-situ of the testis | Edward Thomas Brackenbury

Published by University of Manchester in Manchester .

Written in English

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Edition Notes

Thesis (Ch.M.), - University of Manchester, Faculty of Medicine.

Book details

ContributionsUniversity of Manchester. Faculty of Medicine.
The Physical Object
Pagination155p.
Number of Pages155
ID Numbers
Open LibraryOL16573346M

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Management and Biology of Carcinoma in situ and Cancer of the Testis: 3rd Copenhagen Workshop, November Proceedings (European Urology): Medicine & Health Science Books. Carcinoma in situ of contralateral testis in patients with testicular germ cell cancer: study of 27 cases in patients (with editorial comment by J.

Gillenwater). In: Year Book of Urology. Edited by J. Gillenwater and S. by:   Carcinoma in situ of the testis (CIS) is the uniform precursor of testicular germ-cell tumours. Morphologically, CIS consists of large, intratubular, gonocyte-like cells with large nuclei and abundant glycogen.

CIS cells are probably derived from primordial germ cells and are supposed to be present in the testis of a future testis cancer patient at the time of birth. Pedersen KV, Boisen P, Zetterlund CG () Experience of a screening for carcinoma-in-situ of the testis among young men with surgically corrected maldescended testes.

I: Rørth M, Grigor KM, Giwercman A, Daugaard G, Skakkebaek NE, eds. Carcinoma-in-situ and cancer of the testis. Biology and treatment. Oxford: Blackwell Google ScholarCited by: 1. A case of a malignant undifferentiated germ cell tumor in situ of an undescended testis diagnosed by needle biopsy is described.

Four similar cases have been so far recorded in the literature, all of Cited by: PUGH and his colleagues established a somewhat comparable classification, the British Testicular Tumor Panel classification.

Skakkebaek and colleagues, through numerous publications, have demonstrated the importance of carcinoma in situ, or intratubular germ cell neoplasia, defining the pathogenesis of germ cell tumors. Atlas on the Human Testis: Normal Morphology and Pathology presents histological illustrative material from paraffin and semi-thin sections of the human testis which are routinely used in the assessment of testicular morphology, allowing an early detection of carcinoma in situ and more advanced pathological changes of the testicular parenchyma.

The early detection of cancer in situ is based on Carcinoma-in-situ of the testis book 1. Testicular germ cell tumors can be prevented if the neoplasia is diagnosed at the stage of carcinoma in situ (CIS). Hyperdiploid DNA content is one of the markers of CIS germ cells.

We developed a noninvasive procedure for detection of CIS of the testis by means of a nonradioactive in situ hybridization assay with a probe for chromosome 1.

Niels E. Skakkebæk, Jørgen G. Berthelsen, Carcinoma‐in‐situ of the testis and invasive growth of different types of germ cell tumours. A revised germ cell theory, International Journal of Andrology, /jtbx, 4, s4, (), ().

EAU How to Manage Testicular Microlithiasis and Carcinoma in Situ () As part of a plenary presentation at the European Association of Urology (EAU) Virtual meeting assessing “Testis cancer and surgical andrology,” Marij Dinkelman-Smit, PhD, outlined an approach to testicular microlithiasis and germ-cell Carcinoma-in-situ of the testis book in.

A light microscopical study on a total of consecutive testicular biopsies from infertile men revealed intratubular changes in germ cells compatible with a carcinoma in situ pattern in six.

No authors listed. Management and biology of carcinoma in situ and cancer of the testis. Proceedings of the 3rd Copenhagen Workshop NovemberTesticular cancer is cancer that develops in the testicles, a part of the male reproductive system.

Symptoms may include a lump in the testicle, or swelling or pain in the scrotum. Treatment may result in infertility. Risk factors include an undescended testis, family history of the disease, and previous history of testicular cancer.

The most common type is germ cell tumors which are divided. ISBN: OCLC Number: Description: xviii, pages: illustrations ; 25 cm: Contents: Testicular germ cell tumours - an introductory overview, h; advances in tumour imaging, d; tumour markers, ; a comparison of the biology and prognosis of seminoma and non-seminoma, ; prognostic.

PURPOSE: To elucidate the biologic association between germ cell neoplasia and testicular dysfunction, through investigation of Leydig cell function and semen quality in men with carcinoma-in-situ (CIS) of the testis.

PATIENTS AND METHODS: We examined two groups of men, unilaterally orchidectomized for testicular cancer. Biopsy of the contralateral testis had showed CIS in a group of   Formerly known as carcinoma in situ of the testis (CIS), intratubular germ cell neoplasia, unclassified (ITGCN, IGCNU) or testicular intraepithelial neoplasia GCNIS is a better term since the lesion consists of neoplastic gonocyte-like germ cells that are.

After testis-preserving surgery, adjuvant radiation therapy (20 Gy) should be performed. The rationale is that the remaining parenchyma might harbor germ cell neoplasia in situ (GCNIS) [old nomenclature: testicular intraepithelial neoplasia (TIN), carcinoma in situ (CIS) of the testis], potentially leading to locally recurrent TGCT.

Therefore. AETIOLOGY OF TESTICULAR TUMOUR. Cryptorchidism 2. Carcinoma in situ Trauma. Atrophy CRYPTORCHIDISM & TESTICULAR TUMOUR. Risk of Carcinoma developing in undescended testis is 14 to 48 times the normal expected incidence Clinical Staging of Testicular Tumour Staging A or I Staging B or II - Tumour confined to testis.

- Spread to Regional. Atlas on the Human Testis: Normal Morphology and Pathology presents histological illustrative material from paraffin and semi-thin sections of the human testis which are routinely used in the assessment of testicular morphology, allowing an early detection of carcinoma in situ and more advanced pathological changes of the testicular parenchyma.

Testicular tumours are rare in children. Painless scrotal mass is the most frequent clinical presentation. Tumoural markers (alpha-fetoprotein, beta-human gonadotropin chorionic) and hormone levels (testosterone) contribute to the diagnosis and management of a testicular mass in boys.

Ultrasonography is the best imaging modality to study testicular tumours. Testicular tumors in the pediatric population are rare.

By far, germ cell tumors (GCT) are the main group of pediatric testicular tumors. There are two incidence peaks in children: between years and between 15–19 years, often referred to as prepubertal and (post)pubertal age (type I and II), respectively [].In the past, prepubertal children and adolescents with testicular tumors were.

Carcinoma in situ is defined as dysplasia of the entire epithelial layer without invasion of the basement membrane into the underlying tissue. From: Clinical Review of.

and semi thin sections of the human testis which are routinely used in the assessment of testicular morphology allowing an early detection of carcinoma in situ and more atlas on the human testis normal morphology and pathology Posted By J. Rowling Ltd. testicular morphology allowing an early detection of carcinoma in situ and more advanced pathological changes of the testicular parenchyma the early detection of cancer atlas on the human testis normal morphology and pathology Posted By Astrid Lindgren Media Publishing.

Introduction. Testicular germ cell tumour (TGCT) is the commonest malignancy in young Caucasian males, with a lifetime risk of ∼–1% (Huyghe et al., ).TGCT of young adults originate from a common precursor, the carcinoma in situ (CIS) cell (Skakkebaek, ), also known as intratubular germ cell e the high cure rate of testicular cancer, efforts should be made to.

Carcinoma in situ of penis () Definition (NCI_NCI-GLOSS) Abnormal cells are found on the surface of the skin of the penis. These abnormal cells. Experience of screening for carcinoma-in-situ of the testis among young men with surgically corrected maldescended testes.

Int J Androl ; – 43 Aynsley-Green A. Jørgensen N, Müller J, Giwercman A, et al.: Clinical and biological significance of carcinoma in situ of the testis. Cancer Surv 9 (2):[PUBMED Abstract] Dieckmann KP, Loy V: Prevalence of contralateral testicular intraepithelial neoplasia in patients with testicular germ cell neoplasms.

J Clin Oncol 14 (12):  Testis and epididymis - Embryonal carcinoma. Solid, pseudoglandular, alveolar, tubular or papillary patterns Primitive epithelial type cells with minimal features of differentiation.

atlas on the human testis normal morphology and pathology Posted By Danielle Steel Ltd TEXT ID c0f7 Online PDF Ebook Epub Library dysgenesis syndrome and carcinoma in situ testis tumors of the testis and epididymis congenital testis pathology vascular testis pathology new approaches to diagnosing.

NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. testicular morphology allowing an early detection of carcinoma in situ and more advanced pathological changes of the testicular parenchyma springer atlas on the human atlas on the human testis normal morphology and pathology Posted By Stephenie Meyer Media Publishing.

This special thematic issue of Andrology is devoted to testicular cancer, with focus on germ‐cell‐derived tumours and their precursor, carcinoma in situ testis (CIS). Most of the articles are based on the scientific programme (prepared jointly by us) of the 8th Copenhagen Workshop on CIS Testis & Germ Cell Cancer (CIS Workshop), held in Denmark in May Germ cell neoplasia in situ (GCNIS) represents the precursor lesion for many types of testicular germ cell tumors.

As the name suggests, it represents a neoplastic process of germ cells that is confined to the spermatogonial niche. The term GCNIS was introduced with the edition of the WHO classification of urological tumours. Both of the main clinical types of testicular germ cell cancer, seminoma and non-seminoma, are preceded by carcinoma in situ (Skakkebæk et al., ).

It has been shown that the prevalence of carcinoma in situ in a population corresponds quite accurately to the lifetime occurrence of testicular cancer in that population (Giwercman et al. The behaviour of testis tumors in the elderly is completely different from the younger patient one.

The most frequent histological type are spermatocytic seminoma, malignant Leydig tumors and lymphomas in the testis and sarcomas in the paratesticular e the low incidence of these tumors, the testis is the first site of genitourinary involvement for sarcomas in the elderly.

TESTICULAR CANCER. Testicular cancer is a cancer that originates in one or both testicles, or testes. The testes are the male reproductive glands located inside the pouch of skin located underneath the penis (the scrotum).

The testes are responsible for producing sperm and the hormone, testosterone.

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